Determination of 27 inorganic elements in soft capsule shell by ICP-MS
TAN Jian-ning, QIN Jie-ping
2022, 61(9):
118-122.
doi:10.14088/j.cnki.issn0439-8114.2022.09.023
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A method for the determination of 27 inorganic elements in five vitamin B soft capsule shells by inductively coupled plasma mass spectrometry (ICP-MS) was established. After microwave digestion, the contents of 27 inorganic elements (Li, Be, Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Rb, Sr, Ag, Cd, Cs, Ba, Tl, Pb, U, Hg, etc) in soft capsules were determined by ICP-MS. The results showed that the mass-number ratios of 27 elements and internal standard elements within a certain concentration range had a good linear relationship with the concentration, with the correlation coefficient r≥0.999 0. The detection limits of the instrument were 0.002~1.010 μg/L. The average recoveries of 27 inorganic elements were 82.90%~110.82%, and the RSD was ≤ 5.41%(n=3). The method is simple, rapid, sensitive and accurate, which is suitable for the determination of inorganic elements in the soft capsule shell.