Effect of epigallocatechin gallate on lipid deposition and liver anti-oxidative capacity in heat-stressed broilers
LI Zhen-jun, WU Han, YANG Ye
2020, 59(23):
130-133.
doi:10.14088/j.cnki.issn0439-8114.2020.23.029
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This study aims to investigate the effects of EGCG on the lipid deposition and liver anti-oxidative capacity of broilers under heat stress.One hundred and ninety-two 2-wk-old broilers were divided into four groups with 6 replicates per group and 8 chickens per replicate.One thermoneutral control group (28°C,TN group),which was fed the basal diet;And three cyclic high-temperature groups (35°C from 7:00 to 19:00;28°C from 19:00 to 7:00,heat stress (HS) group),which were fed the basal diet with added EGCG at doses of 0 mg/kg (HS0 group),300 mg/kg (HS300 group),and 600 mg/kg (HS600 group),respectively.The growth performance and liver metabolism and lipid deposition indices were performed at 35 d of age.The results showed that heat stress significantly reduced body weight,daily weight gain,daily feed intake,and decreased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px),and the Nrf2 mRNA expression in liver,and increase significantly the levels of malondialdehyde (MDA) and the expression of LITAF,NF-κB,FAS,SREBP1 mRNA and the lipid deposition compared with TN group.EGCG (HS300 and HS600 group) increased the activities of SOD and GSH-Px and catalase (CAT),and increased the Nrf2 mRNA expression,and decreased the MAD contents,and reduced the lipid deposition and expression of LITAF,NF-κB,FAS,SREBP1 mRNA.The results of this study show that EGCG can improve liver antioxidative capacity to alleviate oxidative damage caused by heat stress.