Extraction process of total flavonoids from stigma maydis and Gynostemma pentaphyllum and preparation of the antihypertensive tablets

doi:10.14088/j.cnki.issn0439-8114.2024.04.025

Abstract

Abstract: Taking stigma maydis and Gynostemma pentaphyllum （1∶1） as the extraction raw material and the total flavonoids content as the investigation index, the effect of compound total flavonoids content was investigated by single factors including extraction solvent, ethanol volume fraction, extraction temperature, extraction time, material-liquid ratio and extraction times. Then, the extraction process of total flavonoids was optimized by the orthogonal test. Finally, the optimized total flavonoids were refined by D101 macroporous adsorption resin and prepared into antihypertensive tablets. The results showed that the best extraction process of compound total flavonoids was 50% ethanol volume fraction, the material-liquid ratio was 1∶10, and the extraction time was 3.5 h at 50 ℃. The quality of the prepared tablets （weight difference ±5.1%, fragmentability 0.83%, disintegration time 2.41 min） was in line with the relevant provisions of the Pharmacopoeia of the People’s Republic of China （2020 edition）, and the antihypertensive tablets could reduce the blood pressure of SHR rats.

Key words: stigma maydis, Gynostemma pentaphyllum, total flavonooids, extraction process, antihypertensive tablets, preparation

CLC Number:

R284

LIU Xia, MA Ze-gang, MA Lin. Extraction process of total flavonoids from stigma maydis and Gynostemma pentaphyllum and preparation of the antihypertensive tablets[J]. HUBEI AGRICULTURAL SCIENCES, 2024, 63(4): 136-140.

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