Effects of LncRNA on embryonic development

doi:10.14088/j.cnki.issn0439-8114.2021.21.005

Abstract

Abstract: Long non-coding RNA （LncRNA） is a class of genomic transcripts with a transcript length of more than 200 nt but no protein-coding ability. Studies have shown that LncRNA can regulate gene expression at pre-transcriptional, transcriptional and post-transcriptional levels, and participate in epigenetic modification, X chromosome dose compensation and genomic imprinting. Embryonic development is a complex and orderly process, which is affected by a series of events, such as maternal to zygotic transition （MZT） and zygotic genome activation （ZGA）. Current studies suggest that LncRNA can affect embryonic development by participating in oocyte maturation, spermatogenesis, ZGA, and regulating the pluripotency of Embryonic stem cells （ESCs）. The research progress on the mechanism of LncRNA in embryonic development was reviewed, which laid the foundation for a comprehensive analysis of the mechanism of LncRNA heterogeneity in preimplantation embryos and its association with cell fate determination.

Key words: LncRNA, embryonic development, ZGA, ESCs

CLC Number:

Q522

ZHANG Yan-di, REN Hong-yan, BI Yan-zhen. Effects of LncRNA on embryonic development[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(21): 26-29.

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