Research progress on antimicrobial active components and action mechanism of Cinnamomi ramulus

doi:10.14088/j.cnki.issn0439-8114.2021.21.004

Abstract

Abstract: Cinnamomi ramulus is an indispensable medicine in many classic prescriptions in China. It mainly contains volatile oil, organic acids and coumarins. Cinnamaldehyde in the essential oil is the main effective component of Cinnamomi ramulus, and also the main active component for antimicrobial activity. Other components in Cinnamomi ramulus, such as cinnamic acid, coumarin, protocatechuic acid, eugenol and cinnamyl alcohol, also have antimicrobial activity activity. Through consulting the relevant literature, the main antibacterial components, antimicrobial effect and mechanism of action of Cinnamomi ramulus were sorted and analyzed to provide reference for clinical application, new medicinal value mining and resource development and utilization of Cinnamomi ramulus.

Key words: Cinnamomi ramulus, cinnamaldehyde, antimicrobial activity, mechanism of action

CLC Number:

R282

WEI Lu-ling, ZHANG Miao, HUANG Piao-ling, TENG Jian-bei. Research progress on antimicrobial active components and action mechanism of Cinnamomi ramulus[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(21): 21-25.

References

[1] 国家药典委员会. 中华人民共和国药典(一部)[M]. 北京:中国医药科技出版社,2020.288-289.
[2] 阴健,郭力弓. 现代中药研究与临床应用[M]. 北京:学苑出版社,1994.536.
[3] 邱琴, 刘廷礼, 崔兆杰, 等. 桂枝挥发油化学成分的GC/MS分析[J]. 药物分析杂志,2000(4):248-251.
[4] 沈群, 陈飞龙, 罗佳波. 桂枝、肉桂挥发油化学成分GC-MS分析[J]. 中药材,2002(4): 257-258.
[5] MOOYOTTU S,KOLLANOOR-JOHNY A,FLOCK G, et al.Carvacrol and trans-cinnamaldehyde reduce Clostridium difficile toxin production and cytotoxicity in vitro[J]. International journal of molecular sciences, 2014, 15(3):4415-4430.
[6] HONG W L, SHENG W M,ZHENG X A, et al.An in vitro investigation of the inhibitory mechanism of β-galactosidase by cinnamaldehyde alone and in combination with carvacrol and thymol[J]. BBA-general subjects, 2017, 1861(1): 3189-3198.
[7] YOSSA N, PATEL J, MACARISIN D, et al.Antibacterial activity of cinnamaldehyde and sporan against Escherichia coli O 157:H 7 and Salmonella[J]. Journal of food processing and preservation, 2014,38(3):749-757.
[8] 王帆, 杨静东, 王春梅, 等. 肉桂醛对大肠杆菌和绿脓杆菌的作用机制[J]. 江苏农业学报,2011,27(4):888-892.
[9] 何学文, 戴雨芸, 李欣越, 等. 肉桂醛体外对鼠伤寒沙门氏菌的抑菌机制[J]. 江西农业大学学报,2020,42(1):150-156.
[10] 薛京昌, 徐晓怡, 郑海松. 肉桂醛对4种常见细菌的体外抑菌实验研究[J]. 检验检疫学刊,2013,23(4):50-53.
[11] 马江伟. 丁香酚及肉桂醛对嗜肺军团菌的抗菌作用及机制的研究[D]. 沈阳:中国医科大学,2018.
[12] 邓洁华,李继红,祁晓明,等. 桂皮醛抗曲霉的敏感性及对烟曲霉细胞壁的影响[J]. 中国真菌学杂志,2018,13(6):345-349.
[13] POOTONG A, NORRAPONG B, COWAWINTAWEEWAT S.Antifungal activity of cinnamaldehyde against Candida albicans[J]. The southeast Asian journal of tropical medicine and public health,2017, 48(1):150-158.
[14] XU L C, TAO N G, YANG W H, et al.Cinnamaldehyde damaged the cell membrane of Alternaria alternata and induced the degradation of mycotoxins in vivo[J]. Industrial crops & products, 2018, 112(3): 427-433.
[15] 王玉珏. 桂皮醛溶液对内氏放线菌的LTA诱导牙周膜成纤维细胞产生TNF-α影响的研究[D].贵州遵义:遵义医学院, 2011.
[16] 张永帅,王淼焱,孙俊良,等. 肉桂醛及其衍生物对四种病原菌的抑菌效果[J].河南科技学院学报(自然科学版),2014,42(4):26-29.
[17] 郭都, 张文婷, 郝旭昇, 等. 反式肉桂醛对副溶血性弧菌的抑制作用[J]. 食品与生物技术学报, 2020, 39(1): 14-23.
[18] 徐多多, 高阳, 潘志, 等. 肉桂酸等4种单体对细菌生物膜的影响[J]. 畜牧与饲料科学, 2011, 32(12): 5,11.
[19] 梁盛年, 段志芳, 付莉, 等. 几种肉桂酸衍生物与肉桂酸的抑菌作用比较研究[J]. 食品科技, 2005(9): 71-73.
[20] 张春乐, 宋康康, 陈祥仁, 等. 肉桂酸及其衍生物的抑菌活性研究[J]. 厦门大学学报(自然科学版), 2006,45(z1): 16-18,72.
[21] 柯莉娜, 胡泳华, 高焕娟, 等. 肉桂酸及其衍生物对双孢蘑菇致腐微生物的体外抑菌效果比较[J]. 厦门大学学报(自然科学版), 2016, 55(3): 330-335.
[22] 张萍,吴丹,矫佳陈琦,等. 产原儿茶酸北五味子内生细菌WF17的鉴定及抑菌活性研究[J]. 中国食品学报, 2015, 15(7): 198-202.
[23] LIU K S, TSAO S M, YIN M C.In vitro antibacterial activity of roselle calyx and protocatechuic acid[J]. Phytother Res, 2005, 19(11):942-945.
[24] 柴贝贝, 姜维佳, 王莉贞, 等. 原儿茶酸或绿原酸与抗菌药联用对鱼源链球菌的抑菌效果[J]. 南方农业学报, 2018, 49(3): 580-585.
[25] 石超. 柠檬醛对阪崎克罗诺肠杆菌抑菌和抗感染作用及其分子机制[D]. 陕西杨凌:西北农林科技大学, 2017.
[26] LIU W H, HSU C C, YIN M C.In vitro anti-Helicobacter pylori activity of diallyl sulphides and protocatechuic acid[J]. Phytother Res, 2008, 22(21):53-57.
[27] CHAO C Y, YIN M C.Antibacterial effects of roselle calyx extracts and protocatechuic acid in ground beef and apple juice[J]. Foodborne pathogens and disease, 2009,6(2):201-206.
[28] LI Z P, LI J, QU D, et al.Synthesis and pharmacological evaluations of 4-hydroxycoumarin derivatives as a new class of anti-Staphylococcus aureus agents[J]. The journal of pharmacy and pharmacology, 2015, 67(4):573-582.
[29] XU Z Q, PUPEK K, WILLIAM J S, et al.Pyranocoumarin, a novel anti-TB pharmacophore:Synthesis and biological evaluation against Mycobacterium tuberculosis[J]. Bioorganic & medicinal chemistry, 2006,14(13):4610-4626.
[30] LUISELLA V,ERMINIO L,GIOVANNI V,et al.4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials[J]. Phytochemistry,2004,65(21):2867-2879.
[31] ADRINAN B, SERGIO S, VIVIENE S, et al.Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae)[J]. Molecules (Basel, Switzerland), 2009, 14(3): 939-952.
[32] LEE J H, KIM Y G, HYUN S C, et al.Coumarins reduce biofilm formation and the virulence of Escherichia coli O157:H7[J].Phytomedicine, 2014, 21(8-9): 1037-1042.
[33] GUTIERREZ -BARRANQUERO J A,JERRY R F,RONAN R M, et al. Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens[J]. Applied microbiology and biotechnology,2015,99(7):3303-3316.
[34] 马艳玲, 李海贤, 曾荣. 丁香酚对金黄色葡菌球菌抗菌作用的探究[J]. 中国酿造, 2017, 36(8): 130-133.
[35] 曾荣, 陈金印, 林丽超. 丁香精油及丁香酚对食品腐败菌的抑菌活性研究[J]. 江西农业大学学报, 2013, 35(4): 852-857.
[36] 李姝毅, 马秋华, 杨蓉娅, 等. 丁香酚体外抗阿萨希毛孢子菌作用研究[J]. 中药药理与临床, 2013, 29(4): 61-63.
[37] 吕世明, 陈杖榴, 陈建新, 等. 丁香酚体外抑菌作用研究[J]. 食品科学, 2008(9): 122-124.
[38] 李维峰, 宋启示, 项伟, 等. 广州蛇根草化学成分及其抗菌活性的研究[J]. 天然产物研究与开发,2014,26(5): 683-686.
[39] 贺菊萍, 赵勇, 孙晓红, 等. 牛蒡皮抑菌性能及其抑菌组分研究[J]. 食品工业, 2014,35(5):178-182.
[40] 杨秀芳, 王改利, 马养民, 等. 水杨梅中化学成分活性的研究[J]. 陕西科技大学学报(自然科学版), 2014,32(1):123-127.
[41] 夏忠弟, 毛学政, 罗映辉. α-蒎烯抗真菌机制的研究[J]. 湖南医科大学学报, 1999, 24(6):507-509.
[42] 石超峰, 殷中琼, 魏琴,等. α-松油醇对大肠杆菌的抑菌作用及其机理研究[J]. 畜牧兽医学报, 2013,44(5):796-801.
[43] 欧阳秋丽, 贾雷, 陶能国, 等. α-松油醇对意大利青霉的抑制作用[J]. 食品科学, 2014,35(11):32-35.
[44] 韩杰, 苏裕心, 陈金龙, 等. α-松油醇杀菌效果的试验观察[J]. 中国消毒学杂志, 2014, 31(4): 333-335.
[45] 赖开平, 叶一强, 韦志明, 等. 左旋松油醇对植物病原菌的抑菌活性研究[J]. 化工技术与开发,2007(12):5-7.
[46] 申素霞. 植物源食品防腐剂的筛选及肉桂醛的抑菌机制研究[D]. 长春:吉林大学, 2015.
[47] GIL R, KEBEDE BINIAM T, ANN V L, et al.Membrane fatty acid composition as a determinant of Listeria monocytogenes sensitivity to trans-cinnamaldehyde[J]. Research in microbiology, 2017, 168(6): 536-546.
[48] SHREAZ S,SHIEKH R A,RAJA V,et al.Impaired ergosterol biosynthesis mediated fungicidal activity of Co(II) complex with ligand derived from cinnamaldehyde[J]. Chemico-biological interactions, 2016,247:64-74.
[49] LI T T,WANG D F,LIU N,et al.Inhibition of quorum sensing-controlled virulence factors and biofilm formation in Pseudomonas fluorescens by cinnamaldehyde[J]. International journal of food microbiology, 2018,269: 98-106.
[50] SHEIKH S, RIMPLE B, NEELOFAF K, et al.Cinnamic aldehydes affect hydrolytic enzyme secretion and morphogenesis in oral Candida isolates[J]. Microbial pathogenesis,2012,52(5): 251-258.
[51] DOMADIA P, SWARUP S, BHUNIA A, et al.Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde[J]. Biochemical pharmacology, 2007, 74(6): 831-840.
[52] HE T F, ZHANG Z H, ZHENG X A,et al.Determination of membrane disruption and genomic DNA binding of cinnamaldehyde to Escherichia coli by use of microbiological and spectroscopic techniques[J]. Journal of photochemistry & photobiology, B:biology, 2018,178: 623-630.
[53] LIU S Y, HOU Y L, LIU W G, et al.Components of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targets[J]. Eukaryotic cell, 2015, 14(4): 324-334.
[54] HEUSINKVELD H J, MOLENDIJK J, VAN DEN BERG M, et al. Azole fungicides disturb intracellular Ca²+ in an additive manner in dopaminergic PC₁₂ cells[J]. Toxicological sciences, 2013, 134(2): 374-381.
[55] 孙琦. 肉桂醛对黄曲霉菌生长和产毒的影响机制研究 [D]:北京:中国农业科学院,2016.
[56] YOUN H S, LEE J K, CHOI Y J, et al.Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization[J]. Biochemical pharmacology, 2008, 75(2): 494-502.
[57] 马克龙, 韩志君, 潘敏, 等. 肉桂醛对白念珠菌定植下DSS诱导的溃疡性结肠炎小鼠治疗作用及对dectin-1/TLRs/NF-κB信号通路的影响[J]. 中国中药杂志, 2020, 45(13):3211-3219.
[58] 龙凯, 谢小梅, 方建如, 等. 肉桂醛、柠檬醛对烟曲霉色素及关键基因alb1 mRNA表达的影响[J]. 微生物学通报,2007(3): 541-544.
[59] 饶春晖, 陆淼炯, 杨燕. 原儿茶酸对金黄色葡萄球菌性肺炎模型小鼠的保护作用及相关机制研究 [J]. 浙江中西医结合杂志,2018,28(11): 911-915,987-988.
[60] 陈玉环,万春鹏,彭旋,等. 桂枝主要抑菌活性成分对柑橘青霉病菌的作用机制研究[J]. 现代食品科技,2016,32(10):45-51,65.