Abstract: E. coli salpingitis in adult chickens caused by pathogenic E. coli was clinically characterized by high morbidity, high mortality rate and high elimination rate. After the outbreak of the chicken farm, it was difficult to control the development of the disease; the purification measures were not only costly but not easily successful. The principle and method of antimicrobial drug selection from the perspective of practice were proposed, and drug guidance and reference for the effective prevention of E. coli disease in laying hens were provided.

Key words: pathogenic E. coli, antibiotics