Research progress of calmodulin binding site regulating cyclic nucleotide-gated ion channels

doi:10.14088/j.cnki.issn0439-8114.2021.20.001

Abstract

Abstract: Cyclic nucleotide-gated ion channels （CNGC） are non-selective cation channels, regulated by intracellular messenger small molecule cyclic nucleotides （cAMP and cGMP） and Ca²⁺/CaM. The allosteric regulation mechanism of mammalian CNGC function is affected by the binding of CaM, and mammalian CNGC has CaMBD at the cytoplasmic N and/or C-terminus. In plants side,most of the research has focused on the C-terminal CaM binding domain （CaMBD） that overlaps with the cyclic nucleotide binding domains of plant CNGC. However, recent studies on the model plant Arabidopsis CNGC12 has provided evidence that a single plant CNGC isoform has multiple CaMBDs. This review focuses on the research progress in the regulation of calmodulin binding sites in plant and animal cyclic nucleotide-gated ion channels.

Key words: cyclic nucleotide-gated ion channels, calmodulin, cyclic nucleotide

CLC Number:

Q342

YU Bing-qing, YAN Han-chi. Research progress of calmodulin binding site regulating cyclic nucleotide-gated ion channels[J]. HUBEI AGRICULTURAL SCIENCES, 2021, 60(20): 5-9.

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