HUBEI AGRICULTURAL SCIENCES ›› 2021, Vol. 60 ›› Issue (20): 5-9.doi: 10.14088/j.cnki.issn0439-8114.2021.20.001

• Reviews •     Next Articles

Research progress of calmodulin binding site regulating cyclic nucleotide-gated ion channels

YU Bing-qing, YAN Han-chi   

  1. School of Life Sciences,Tianjin University,Tianjin 300072,China
  • Received:2020-08-02 Online:2021-10-25 Published:2021-11-05

Abstract: Cyclic nucleotide-gated ion channels (CNGC) are non-selective cation channels, regulated by intracellular messenger small molecule cyclic nucleotides (cAMP and cGMP) and Ca2+/CaM. The allosteric regulation mechanism of mammalian CNGC function is affected by the binding of CaM, and mammalian CNGC has CaMBD at the cytoplasmic N and/or C-terminus. In plants side,most of the research has focused on the C-terminal CaM binding domain (CaMBD) that overlaps with the cyclic nucleotide binding domains of plant CNGC. However, recent studies on the model plant Arabidopsis CNGC12 has provided evidence that a single plant CNGC isoform has multiple CaMBDs. This review focuses on the research progress in the regulation of calmodulin binding sites in plant and animal cyclic nucleotide-gated ion channels.

Key words: cyclic nucleotide-gated ion channels, calmodulin, cyclic nucleotide

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