Abstract: In order to explore the therapeutic effect of compound rhubarb purifying solution enema on chronic renal failure rats, it was divided into pathological control group, medicinal charcoal group, large, medium and small dose of compound rhubarb purifying solution enema treatment group by copying chronic renal failure model, the medication period was 58 d. The changes of serum creatinine, urea nitrogen, urine creatinine, red blood cell count, hemoglobin content, and renal histopathology were observed. Results showed that the blood muscle crispness and urea nitrogen of the compound rhubarb purifying solution in each dose group and the medicinal charcoal group were significantly reduced （P<0.05）, and the decline was more significant in the large and medium dose groups （P<0.05）. The 24-hour urinary muscle crunch in each dose group was significantly increased （P<0.05）, and it was significant in the large and medium dose groups （P<0.05）; the red blood cell count and hemoglobin content in the large and medium dose groups of compound rhubarb cleansing solution were significant increased （P<0.05）; each dose group of enema formula can improve renal pathological changes in rats with renal failure to varying degrees. Compound rhubarb purifying solution had certain effects on improving renal function, renal pathology, and anemia in rats with chronic renal failure, and had a certain amount of effect.

Key words: chronic renal failure, compound rhubarb purifying solution, serum creatinine, urea nitrogen, urinary creatinine