Abstract: During the screening process of natural products produced by actionmycetes,a strain HBERC-21542 was isolated from soil samples collected in Leshan district,Sichuan province. The fermentation extract exhibited strong insectcidal activities against some insects such as Plutella xylostell,Helicoverpa armigera,etc. It was determined by components bioassay that the active compounds were in between 14~19 min in HPLC profile,and the active compound was identified as Ferensimycin A based on MS,UV absoption spectrum and natural product dictionary. Pure compound of 90% was obtained by preparative HPLC,and the lethal rate was 90%~100% at 50 μg/mL against Plutella xylostell,Helicoverpa armigera.

Key words: natural products, insectcidal activity, actinomycetes, Ferensimycin A