噬菌体裂解酶的应用概况

doi:10.14088/j.cnki.issn0439-8114.2019.10.001

摘要/Abstract

摘要： 近年来由于耐药菌的频频出现,抗生素在抗感染领域面临前所未有的挑战,目前研制可裂解病原菌的噬菌体制剂已为一大热点。噬菌体裂解酶是双链DNA噬菌体在基因组复制晚期合成的一类蛋白质,它能够水解细菌细胞壁中的肽聚糖从而杀灭细菌。噬菌体裂解酶在体内外的试验中都表现出很高的杀菌性、种属特异性和安全性,因而具有广阔的应用前景。简要介绍了噬菌体裂解酶的结构性质,并对裂解酶显示出的抗菌性能及应用进行了综述。

关键词: 噬菌体, 裂解酶, 耐药菌

Abstract: More recently, the original application of phage as therapeutics to treat human and animal infections has been rekindled, particularly in an era where antibiotic resistance has become so problematic. Bacteriophage lysins,which are peptidoglycan hydrolases encoded by double-stranded DNA bacteriophage, are produced in phage-infected bacterial cells toward the end of the lytic cycle. It was proved that the phage lysins exhibited high activity against bacteria, narrow antibacterial spectrum, and apparent safety in vitro and vivo experiments. Those paved solid foundation for further exploration of their application. A review on the structure and mode of action of lysins and their application were presented.

Key words: bacteriophage, lysin, antibiotic resistant bacteria

中图分类号:

S562

严晶, 胡申才. 噬菌体裂解酶的应用概况[J]. 湖北农业科学, 2019, 58(10): 5-8.

YAN Jing, HU Shen-cai. The application profile of bacteriophage lysins[J]. HUBEI AGRICULTURAL SCIENCES, 2019, 58(10): 5-8.

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