[1] 李杰, 尚孟文, 李婼楠,等.黄芩中3种黄酮水热法提取工艺的优化[J].中成药, 2020, 42(9):2427-2430. [2] LIU R X, SONG G H, WU P G, et al.Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis[J].Chinese journal of natural medicines, 2017, 15(2):152-160. [3] ZHAO T T, TANG H L, XIE L, et al.Scutellaria baicalensis Georgi. (Lamiaceae): A review of its traditional uses, botany, phytochemistry, pharmacology and toxicology[J]. Journal of pharmacy and pharmacology, 2019, 71(9):1353-1369. [4] 郭兰萍, 吕朝耕, 王红阳, 等. 中药生态农业与几种相关现代农业及GAP的关系[J].中国现代中药, 2018, 20(10):1179-1188. [5] QUAN J X, SONG S S, ABDULRASHID K, et al.Separate and combined response to UV-B radiation and jasmonic acid on photosynthesis and growth characteristics of Scutellaria baicalensis[J]. International journal of molecular sciences, 2018, 19(4):1194. [6] YANG L,WEN K S,RUAN X,et al.Response of plant secondary metabolites to environmental factors[J]. Molecules,2018,23(4):762. [7] NABAVI S M, ŠAMEC D, TOMCZYK M, et al.Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering[J]. Biotechnology advances, 2020, 38:107316. [8] KIM Y S, KIM Y B, KIM Y J, et al.Overexpression of cinnamate 4-hydroxylase and 4-coumaroyl CoA ligase prompted flavone accumulation in Scutellaria baicalensis hairy roots[J]. Natural product communications, 2014, 9(6):803-807. [9] BASU S, RAMEGOWDA V, KUMAR A, et al.Plant adaptation to drought stress[J]. F1000Research, 2016, 5: 1554. [10] SELMAR D, KLEINWÄCHTER M. Influencing the product quality by deliberately applying drought stress during the cultivation of medicinal plants[J]. Industrial crops and products, 2013, 42:558-566. [11] 程林. 干旱胁迫黄芩生理生态变化及其黄芩苷生物合成的分子生态机制[D]. 长春:吉林农业大学, 2018. [12] 管仁伟, 郭瑞齐, 林慧彬, 等. 基于植物代谢组学技术的干旱及盐胁迫对黄芩中黄酮类成分影响的研究[J].中草药,2022, 53(5):1504-1511. [13] CHENG L, HAN M, YANG L M, et al.Changes in the physiological characteristics and baicalin biosynthesis metabolism of Scutellaria baicalensis Georgi under drought stress[J]. Industrial crops and products, 2018, 122;473-482. [14] YUAN Y, QI L J, YANG J, et al.A Scutellaria baicalensis R2R3-MYB gene, SbMYB8, regulates flavonoid biosynthesis and improves drought stress tolerance in transgenic tobacco[J]. Plant cell, tissue and organ culture,2015, 120(3):961-972. [15] YUAN Y,WU CHONG,LIU Y J, et al.The Scutellaria baicalensis R2R3-MYB transcription factors modulates flavonoid biosynthesis by regulating GA metabolism in transgenic tobacco plants[J]. PLoS One, 2017, 8(10):e77275. [16] QI L J,YANG J,YUAN Y,et al.Overexpression of two R2R3-MYB genes from Scutellaria baicalensis induces phenylpropanoid accumulation and enhances oxidative stress resistance in transgenic tobacco[J]. Plant physiology and biochemistry,2015,94:235-243. [17] 杨晖, 陈四清. 道地药材的环境影响及保护和发展[J].时珍国医国药, 2015, 26(8):1971-1972. [18] 陈顺钦,袁媛,罗毓健,等. 光照对黄芩黄酮类活性成分积累及其相关基因表达的影响[J]. 中国中药杂志,2010,35(6):682-685. [19] SUN Z W, LIU J H, LI J, et al.Germination characteristics and secondary metabolism regulation of Scutellaria baicalensis Georgi seeds under different light intensities[J].Agricultural science & technology, 2013, 14(6):842-846. [20] 蔡葛平. 光周期、土壤水分及外源激素对黄芩中黄酮类成分累积的影响及其分子机制[D]. 上海:复旦大学, 2008. [21] TREUTTER D.Significance of flavonoids in plant resistance and enhancement of their biosynthesis[J]. Plant biol(Stuttg), 2005, 7(6):581-591. [22] QUAN J X, SONG S S, ABDULRASHID K, et al.Separate and combined response to UV-B radiation and jasmonic acid on photosynthesis and growth characteristics of Scutellaria baicalensis[J]. International journal of molecular sciences, 2018, 19(4):1194. [23] TANG W T, FANG M F, LIU X, et al.Simultaneous quantitative and qualitative analysis of flavonoids from ultraviolet-B radiation in leaves and roots of Scutellaria baicalensis Georgi using LC-UV-ESI-Q/TOF/MS[J]. Journal of analytical methods in chemistry, 2014, 2014:643879. [24] 张进杰,徐茂军,周桂飞. 光质对悬浮培养黄芩细胞生长及黄芩苷积累的影响[J].热带亚热带植物学报,2007,15(2):135-140. [25] 陈顺钦,黄璐琦,袁媛,等. 光照对黄芩悬浮细胞内源激素与有效成分相关性的影响[J].中国实验方剂学杂志,2010,16(4):72-74. [26] 齐婧婉, 杨景明, 姜华. 环境因素与药用植物次生代谢产物关系的研究现状[J].锦州医科大学学报,2019,40(5):107-110. [27] 侯云亮,韩梅, 杨利民, 等. 温度对黄芩愈伤组织中黄芩苷含量及关键酶基因表达的影响[J]. 中国中药杂志,2018,43(13):2670-2675. [28] YUAN Y, LIU Y J, LUO Y J, et al.High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells[J]. African journal of biotechnology, 2011, 10(26):5182-5192. [29] 王帅. 黄芩愈伤组织黄芩苷次生代谢对温度变化的响应[D]. 长春:吉林农业大学, 2018. [30] ASGARI LAJAYER B,GHORBANPOUR M,NIKABADI S.Heavy metals in contaminated environment: Destiny of secondary metabolite biosynthesis, oxidative status and phytoextraction in medicinal plants[J]. Ecotoxicology and environmental safety,2017,145:377-390. [31] LI Y M, LIU J Z, SHI Y B, et al.Effects of aluminum stress on the stomata characteristics and photosynthesis of Scutellaria baicalensis Georgi seedlings[J].Medicinal plant, 2011, 2(1):5-8. [32] 刘岩,李连泰,计小清,等.土壤中无机元素对不同产地黄芩中无机元素和黄芩苷量的影响[J]. 中草药,2017,48(6):1225-1228. [33] 赵曼茜, 吕金嵘, 郭兰萍, 等. 土壤无机元素对黄芩无机元素及黄芩苷含量的影响[J].中国实验方剂学志, 2010, 16(9):103-106. [34] CAO H B, JIANG Y, CHEN J J, et al.Arsenic accumulation in Scutellaria baicalensis Georgi and its effects on plant growth and pharmaceutical components[J]. Journal of hazardous materials, 2009, 171(1-3):508-513. [35] GUO L P, WANG S, ZHANG J, et al.Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism[J]. Science China life sciences, 2013, 56(11):1047-1056. [36] 孟庆华, 张栓. 微量元素对黄芩有效成分积累的影响[J].陕西中医学院学报, 2012, 35(5):88-89. [37] 魏东华, 李林章, 陈淑欣, 等. 不同土壤营养条件对黄芩苷含量的影响[J].中国实验方剂学杂志, 2010, 16(12):56-58. [38] 曹鲜艳, 徐福利, 王渭玲, 等. 黄芩产量和黄芩苷含量对氮磷钾肥料的响应[J].应用生态学报, 2012, 23(8):2171-2177. [39] YASEEN M, AHMAD T, SABLOK G, et al.Review: role of carbon sources for in vitro plant growth and development[J]. Molecular biology reports, 2013, 40(4):2837-2849. [40] PARK C H, KIM Y S, LI X H, et al.Influence of different carbohydrates on flavonoid accumulation in hairy root cultures of Scutellaria baicalensis[J]. Natural product communications,2016,11(6):799-802. |