微藻对抗生素的毒性响应及去除作用

doi:10.14088/j.cnki.issn0439-8114.2022.05.019

摘要/Abstract

摘要： 抗生素在水环境中残留带来的环境隐患不容小觑,作为一种新型的环境污染物,急需一种经济有效的方法将其去除。近几年,微藻水处理技术受到广泛关注,其对抗生素的去除有一定的效果。将抗生素对微藻的毒性效应、微藻去除抗生素的影响因素、去除效率及去除机理的研究进展进行了综述。讨论了未来利用微藻去除抗生素的研究方向,以期对藻类的综合利用提供帮助。

关键词: 抗生素, 微藻, 水处理, 生物毒性, 生物降解

Abstract: The environmental problems caused by antibiotic residues in water environment should not be underestimated. As a new type of environmental pollutant, an economical and effective method should be developed to remove it.In recent years, microalgae-based water treatment technology had been paid more attention because it had certain effect on the removal of antibiotics. The toxic effects of antibiotics on microalgae, the influencing factors of microalgae on removal of antibiotics, the removal efficiency and mechanism were reviewed. The future research direction of antibiotic removal by microalgae was discussed, in order to provide help for the comprehensive utilization of algae.

Key words: antibiotic, microalgae, water treatment, biotoxicity, biodegradable

中图分类号:

Q914.83

李雅琪, 秦海天, 黄河. 微藻对抗生素的毒性响应及去除作用[J]. 湖北农业科学, 2022, 61(5): 98-105.

LI Ya-qi, QIN Hai-tian, HUANG He. Toxicity response of microalgae to antibiotics and its removal effect[J]. HUBEI AGRICULTURAL SCIENCES, 2022, 61(5): 98-105.

参考文献 87

[1]	HUANG F Y, AN Z Y, MORAN M J, et al.Recognition of typical antibiotic residues in environmental media related to groundwater in China (2009-2019)[J]. Journal of hazardous materials,2020, 399:122813.
[2]	YING G G, HE L Y, YING A J, et al.China must reduce its antibiotic use[J]. Environmental science & technology, 2017, 51(3):1072-1073.
[3]	GULLBERG E, CAO S, BERG O G, et al.Selection of resistant bacteria at very low antibiotic concerntrations[J]. PLoS Pathog, 2011, 7(7): e1002158.
[4]	LIU X H, LU S Y, GU W, et al.Antibiotics in the aquatic environments: A review of lakes, China[J]. Science of the total environment, 2018, 627:1195-1208.
[5]	LI C, CHEN J Y, WANG J H, et al. Occurrence of antibiotics in soils and manures from greenhouse vegetable production bases of Beijing, China and an associated risk assessment[J]. Science of the total environment, 2015, 521-522:101-107.
[6]	KELLY B C, IKONOMOU M G, BLAIR J D, et al.Food web-specific biomagnification of persistent organic pollutants[J]. Science, 2007, 317(5835):236-239.
[7]	世界卫生组织. 抗微生物药物耐药性[EB/OL].https://www.who.int/zh/news-room/fact-sheets/detail/antimicrobial-resistance,2020- 10-13.
[8]	ISIDORI M,LAVORGNA M, NARDELLI A, et al.Toxic and genotoxic evaluation of six antibiotics on non-target organisms[J]. Science of the total environment, 2005, 346(13):87-98.
[9]	KOVALAKOVA P, CIZMAS L, MCDONALD T J, et al.Occurrence and toxicity of antibiotics in the aquatic environment: A review[J]. Chemosphere, 2020, 251:126351.
[10]	BRAIN R A, HANSON M L, SOLOMON K R, et al.Aquatic plants exposed to pharmaceuticals: Effects and risks[J]. Rev Environ Contam Toxicol, 2008, 192(192):67-115.
[11]	ZHOU L J,YING G G,LIU S,et al.Excretion masses and environmental occurrence of antibiotics in typical swine and dairy cattle farms in China[J].Science of the total environment,2013,444(2):183-195.
[12]	ZUCCATO E,CASTIGLIONI S,BAGNATI R,et al.Source, occurrence and fate of antibiotics in the Italian aquatic environment[J]. Journal of hazardous materials, 2010, 179:1042-1048.
[13]	GROS M, PETROVI M, GINEBREDA A, et al.Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes[J]. Environment international, 2010, 36(1):15-26.
[14]	GOU N, YUAN S, LAN J, et al.A quantitative toxicogenomics assay reveals the evolution and nature of toxicity during the transformation of environmental pollutants[J]. Environmental science & technology, 2014, 48(15):8855-8863.
[15]	ZIETZSCHMANN F, STUTZER C, JEKEL M.Granular activated carbon adsorption of organic micro-pollutants in drinking water and treated wastewater-Aligning breakthrough curves and capacities[J]. Water research, 2016, 92:180-187.
[16]	XIONG J, KURADE M B, JEON B, et al.Can microalgae remove pharmaceutical contaminants from water[J]. Trends in biotechnology, 2018, 36(1):30-44.
[17]	WIJFFELS R H, KRUSE O, HELLINGWERF K J.Potential of industrial biotechnology with cyanobacteria and eukaryotic microalgae[J]. Current opinion in biotechnology, 2013, 24(3):405-413.
[18]	ABINANDAN S, SHANTHAKUMAR S.Challenges and opportunities in application of microalgae (Chlorophyta) for wastewater treatment: A review[J].Renewable & sustainable energy reviews, 2015, 52:123-132.
[19]	WANG Y, HO S H, CHENG C L, et al.Perspectives on the feasibility of using microalgae for industrial wastewater treatment[J]. Bioresource technology, 2016, 222:485-497.
[20]	WU Y, LI T, YANG L.Mechanisms of removing pollutants from aqueous solutions by microorganisms and their aggregates: A review[J]. Bioresource technology, 2012, 107(1):10-18.
[21]	CAI T,PARK S Y,LI Y.Nutrient recovery from wastewater streams by microalgae: Status and prospects[J]. Renewable & sustainable energy reviews, 2013, 19:360-369.
[22]	HWANG J H, CHURCH J, LEE S J, et al.Use of microalgae for advanced wastewater treatment and sustainable bioenergy generation[J]. Environmental engineering science,2016, 33(11):882-897.
[23]	KUMAR A, ERGAS S, YUAN X, et al.Enhanced CO2 fixation and biofuel production via microalgae: Recent developments and future directions[J]. Trends in biotechnology, 2010, 28(7):371-380.
[24]	LI C,XIAO S,JU L K.Cultivation of phagotrophic algae with waste activated sludge as a fast approach to reclaim waste organics[J]. Water research, 2016, 91:195-202.
[25]	CUELLAR-BERMUDEZ S P,ALEMAN-NAVA G S,CHANDRA R, et al. Nutrients utilization and contaminants removal. A review of two approaches of algae and cyanobacteria in wastewater[J]. Algal research, 2017,24:438-449.
[26]	SILVA T L, GOUVEIA L, REIS A.Integrated microbial processes for biofuels and high value-added products:The way to improve the cost effectiveness of biofuel production[J]. Applied microbiology & biotechnology, 2014, 98(3):1043-1053.
[27]	LADYGINA N, DEDYUKHINA E G, VAINSHTEIN M B.A review on microbial synthesis of hydrocarbons[J]. Process biochemistry, 2006, 41:1001-1014.
[28]	RAJA R, HEMAISWARYA S, KUMAR N A, et al.A perspective on the biotechnological potential of microalgae[J]. Critical reviews in microbiology, 2008, 34(2):77-88.
[29]	MILLEDGE J J.Commercial application of microalgae other than as biofuels: A brief review[J]. Reviews in environmental science & biotechnology, 2011, 10(1):31-41.
[30]	SPOLAORE P, JOANNIS-CASSAN C, DURAN E, et al.Commercial applications of microalgae[J]. Journal of bioscience & bioengineering, 2006, 101(2):87-96.
[31]	UBEDA B,GALVEZ J A,MICHEL M,et al.Microalgae cultivation in urban wastewater:Coelastrum cf. pseudomicroporum as a novel carotenoid source and a potential microalgae harvesting tool[J]. Bioresource technology, 2017, 228:210-217.
[32]	RAJA R, HEMAISWARYA S, RENGASAMY R.Exploitation of Dunaliella for β-carotene production[J]. Applied microbiology & biotechnology, 2007, 74:517-523.
[33]	PULZ O, GROSS W.Valuable products from biotechnology of microalgae[J]. Applied microbiology & biotechnology,2004, 65(6):635-648.
[34]	甄茜,蔡婕,郭行,等.微藻在废水脱氮除磷中的应用[J].水处理技术, 2017, 43(8):7-12.
[35]	WEN Y, HE Y, JI X, et al.Isolation of an indigenous Chlorella vulgaris from swine wastewater and characterization of its nutrient removal ability in undiluted sewage[J]. Bioresource technology, 2017,243:247-253.
[36]	QU W, ZHANG C, ZHANG Y, et al.Optimizing real swine wastewater treatment with maximum carbohydrate production by a newly isolated indigenous microalga Parachlorella kessleri QWY28[J]. Bioresource technology, 2019, 289:121702.
[37]	程海翔. 一株栅藻的分离培养及其应用于养猪废水处理的潜力研究[D].杭州:浙江大学,2013.
[38]	LUO L, HE H, YANG C, et al.Nutrient removal and lipid production by Coelastrella sp. in anaerobically and aerobically treated swine wastewater[J]. Bioresource technology,2016,216:135-141.
[39]	WANG Y H, LIU J Z, KANG D, et al.Removal of pharmaceuticals and personal care products from wastewater using algae-based technologies: A review[J]. Reviews in environmental science & biotechnology, 2017, 16:717-735.
[40]	NIE X P, LIU B Y, YU H J, et al.Toxic effects of erythromycin, ciprofloxacin and sulfamethoxazole exposure to the antioxidant system in Pseudokirchneriella subcapitata[J]. Environmental pollution,2013, 172:23-32.
[41]	WAN J J, GUO P Y, PENG X F, et al.Effect of erythromycin exposure on the growth, antioxidant system and photosynthesis of Microcystis flos-aquae[J]. Journal of hazardous materials,2015,283:778-786.
[42]	YANG L B,REN L,TAN X B,et al.Removal of Ofloxacin with biofuel production by oleaginous microalgae Scenedesmus obliquus[J]. Bioresource technology, 2020,315:123738.
[43]	XIONG J Q, KURADE M B, KIM J R, et al.Ciprofloxacin toxicity and its co-metabolic removal by a freshwater microalga Chlamydomonas mexicana[J]. Journal of hazardous materials,2017, 323:212-219.
[44]	MAGDALENO A, SAENZ M E, JUAREZ A B, et al.Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata[J]. Ecotoxicology & environmental safety, 2014, 113:72-78.
[45]	XU D M, XIAO Y P, PAN H, et al.Toxic effects of tetracycline and its degradation products on freshwater green algae[J]. Ecotoxicology and environmental safety, 2019, 174:43-47.
[46]	NIE X P, WANG X, CHEN J, et al.Response of the freshwater alga Chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin[J]. Environmental toxicology & chemistry, 2010, 27(1):168-173.
[47]	CHEN S, ZHANG W, LI J Y, et al.Ecotoxicological effects of sulfonamides and fluoroquinolones and their removal by a green alga (Chlorella vulgaris) and a cyanobacterium (Chrysosporum ovalisporum)[J]. Environmental pollution, 2020, 263:114554.
[48]	GUO J H, PENG J L, LEI Y, et al.Comparison of oxidative stress induced by clarithromycin in two freshwater microalgae Raphidocelis subcapitata and Chlorella vulgaris[J]. Aquatic toxicology, 2019, 219:105376.
[49]	MORO I, TRENTIN R, MOSCHIN E, et al.Morpho-physiological responses by Isochrysis galbana Parke to different concentrations of oxytetracycline[J]. Environmental pollution, 2020, 262:114273.
[50]	WAN J J, GUO P Y, ZHANG S X.Response of the cyanobacterium Microcystis flos-aquae to levofloxacin[J]. Environmental science & pollution research, 2014, 21(5):3858-3865.
[51]	XIONG J Q, KURADE M B, JEON B H.Biodegradation of levofloxacin by an acclimated freshwater microalga,Chlorella vulgaris[J]. Chemical engineering journal, 2017,313:1251-1257.
[52]	ADEREMI A O, NOVAIS S C, LEMOS M F, et al.Oxidative stress responses and cellular energy allocation changes in microalgae following exposure to widely used human antibiotics[J]. Aquatic toxicology, 2018, 203:130-139.
[53]	XIONG J Q, KIM S J, KURADE M B, et al.Combined effects of sulfamethazine and sulfamethoxazole on a freshwater microalga Scenedesmus obliquus: Toxicity, biodegradation, and metabolic fate[J]. Journal of hazardous materials, 2018, 370:1-9.
[54]	YANG L H, YING G G, SU H C, et al.Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga Pseudokirchneriella subcapitata[J]. Environmental toxicology & chemistry, 2010, 27(5):1201-1208.
[55]	XIONG J Q, KURADE M B, PATIL D V, et al.Biodegradation and metabolic fate of levofloxacin via a freshwater green alga, Scenedesmus obliquus in synthetic saline wastewater[J]. Algal research, 2017, 25:54-61.
[56]	GONZALEZ-PLEITER M,GONZALO S, RODEA-PALOMARES I, et al.Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: Implications for environmental risk assessment[J]. Water research, 2013, 47(6):2050-2064.
[57]	ROBINSON A A, BELDEN J B, LYDY M J.Toxicity of fluoroquinolone antibiotics to aquatic organisms[J]. Environmental toxicology & chemistry, 2010, 24(2):423-430.
[58]	FU L, HUANG T, WANG S, et al.Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action[J]. Chemosphere, 2017, 168:217-222.
[59]	ADRIAN J G, ANDREA H D, MARTA L, et al.An automated on-line turbulent flow liquid-chromatography technology coupled to a high resolution mass spectrometer LTQ-Orbitrap for suspect screening of antibiotic transformation products during microalgae wastewater treatment[J]. Journal of chromatography A, 2018, 1568(21):57-68.
[60]	REYMANN T, KERNER M, KUMMERER K.Assessment of the biotic and abiotic elimination processes of five micropollutants during cultivation of the green microalgae Acutodesmus obliquus[J]. Bioresource technology reports, 2020, 11:100512.
[61]	SUN M, LIN H, GUO W, et al.Bioaccumulation and biodegradation of sulfamethazine in Chlorella pyrenoidosa[J]. Journal of ocean university of China, 2017, 16(6):1167-1174.
[62]	ZHANG L, GUO R X, LI H T, et al.Mechanism analysis for the process-dependent driven mode of NaHCO3 in algal antibiotic removal:Efficiency,degradation pathway and metabolic response[J]. Journal of hazardous materials, 2020, 394:122531.
[63]	CHEN Z B, HE Z W, TANG C C, et al.Performance and model of a novel multi-sparger multi-stage airlift loop membrane bioreactor to treat high-strength 7-ACA pharmaceutical wastewater: Effect of hydraulic retention time, temperature and pH[J]. Bioresource technology, 2014, 167:241-250.
[64]	LI H, WEI L, LU J.Algae-induced photodegradation of antibiotics: A review[J]. Environmental pollution, 2021,272:115589.
[65]	高静思, 朱佳, 董文艺.光照对我国常见藻类的影响机制及其应用[J]. 环境工程, 2019, 37(5):111-116.
[66]	TIAN Y J, WEI L X, YIN Z, et al.Photosensitization mechanism of algogenic extracellular organic matters (EOMs) in the photo-transformation of chlortetracycline: Role of chemical constituents and structure[J]. Water research, 2019, 164:114940.
[67]	TIAN Y J, WEI L X, YIN Z, et al.Chlorella vulgaris enhance the photodegradation of chlortetracycline in aqueous solution via extracellular organic matters (EOMs): Role of triplet state EOMs[J]. Water research, 2019, 149:35-41.
[68]	FLEMMING H C, WINGENDER J.The biofilm matrix[J]. Nature reviews microbiology, 2010, 8(9):623-633.
[69]	FOMINA M, GADD G M.Biosorption: Current perspectives on concept, definition and application[J]. Bioresource technology, 2014, 160:3-14.
[70]	WANG J,CHEN C.Biosorbents for heavy metals removal and their future[J]. Biotechnology advances, 2009, 27(2):195-226.
[71]	GADD G M.Biosorption: Critical review of scientific rationale, environmental importance and significance for pollution treatment[J]. Chemical technology & biotechnology, 2010, 84(1):13-28.
[72]	STEVENS-GARMON J, DREWES J E, KHAN S J, et al.Sorption of emerging trace organic compounds onto wastewater sludge solids[J]. Water research, 2011, 45:3417-3426.
[73]	DUAN Y P,MENG X Z, WEN Z H, et al.Acidic pharmaceuticals in domestic wastewater and receiving water from hyper-urbanization city of China (Shanghai): Environmental release and ecological risk[J]. Environmental science and pollution, 2013, 20(1):108-116.
[74]	CARRASQUILLO A J, BRULAND G L, MACKAY A A, et al.Sorption of ciprofloxacin and oxytetracycline zwitterions to soils and soil minerals: Influence of compound structure[J]. Environmental science & technology, 2008, 42(20):7634-7642.
[75]	VASUDEVAN D,BRULAND G L,TORRANCE B S,et al.pH-dependent ciprofloxacin sorption to soils: Interaction mechanisms and soil factors influencing sorption[J]. Geoderma,2009,151(3-4):68-76.
[76]	BINELLI A, PROVINI A.The PCB pollution of Lake Iseo (N. Italy) and the role of biomagnification in the pelagic food web[J]. Chemosphere, 2003, 53(2):143-151.
[77]	KIKI C, RASHID A, WANG Y W, et al.Dissipation of antibiotics by microalgae: Kinetics, identification of transformation products and pathways[J]. Journal of hazardous materials, 2019, 387:121985.
[78]	章琴琴,汪昆平,杨林,等.基于液相色谱法分析水环境中大环内酯类抗生素污染的研究进展[J]. 环境化学,2012,31(11):1787-1796.
[79]	CAO D Q, YANG W Y, WANG Z, et al.Role of extracellular polymeric substance in adsorption of quinolone antibiotics by microbial cells in excess sludge[J]. Chemical engineering journal, 2019, 370:684-694.
[80]	BAI X,ACHARYA K. Algae-mediated removal of selected pharmaceutical and personal care products (PPCPs) from Lake Mead water[J]. Science of the total environment,2017,581-582:734-740.
[81]	BAI X, ACHARYA K.Removal of trimethoprim, sulfamethoxazole, and triclosan by the green alga Nannochloris sp.[J]. Journal of hazardous materials, 2016, 315:70-75.
[82]	PRATA J C, LAVORANTE B R B O, MONTENEGRO B S M, et al. Influence of microplastics on the toxicity of the pharmaceuticals procainamide and doxycycline on the marine microalgae Tetraselmis chuii[J]. Aquatic toxicology, 2018, 197:143-152.
[83]	TORRES M A, BARROS M P, CAMPOS S C G, et al. Biochemical biomarkers in algae and marine pollution: A review[J]. Ecotoxicology and environmental safety, 2008, 71(1):1-15.
[84]	ZANGAR R C,DAVYDOV D R,VERMA S.Mechanisms that regulate production of reactive oxygen species by cytochrome P450[J]. Toxicology and applied pharmacology, 2004, 199(3):316-331.
[85]	DIETZ A C, SCHNOOR J L.Advances in phytoremediation[J]. Environmental health perspectives, 2001, 109(s1):163-168.
[86]	PETROUTSOS D, KATAPODIS P, SAMIOTAKI M, et al.Detoxification of 2,4-dichlorophenol by the marine microalga Tetraselmis marina[J]. Phytochemistry, 2008, 69(3):707-714.
[87]	SONG C F, YAN L, QIU Y, et al.Biodegradability and mechanism of florfenicol via Chlorella sp. UTEX1602 and L38: Experimental study[J]. Bioresource technology, 2019, 272:529-534.