湖北农业科学 ›› 2021, Vol. 60 ›› Issue (24): 164-168.doi: 10.14088/j.cnki.issn0439-8114.2021.24.036

• 畜牧·兽医 • 上一篇    下一篇

发酵中药制剂对肉鸡生产性能、免疫功能、肠道形态及盲肠菌群影响的研究

王丹, 崔卫涛, 王纯, 况世昌, 许青荣, 肖运才, 李自力, 周祖涛   

  1. 华中农业大学动物医学院/湖北省预防兽医学重点实验室/生物发酵制剂湖北省工程研究中心,武汉 430070
  • 收稿日期:2021-08-19 出版日期:2021-12-25 发布日期:2022-01-04
  • 通讯作者: 周祖涛,男,副教授,博士,研究方向为兽医微生物与免疫学,(电话)13114373570(电子信箱)ztzhou@mail.hzau.edu.cn。
  • 作者简介:王 丹(1992-),女,宁夏青铜峡人,硕士研究生,研究方向为兽医微生物与免疫学;
  • 基金资助:
    广西创新驱动发展专项(桂科AA18118051); 中央高校基本科研业务费专项基金资助项目(2662016PY103)

Study on the application of fermented Chinese medicine preparation to replace antibiotics in broiler diet

WANG Dan, CUI Wei-tao, WANG Chun, KUANG Shi-chang, XU Qing-rong, XIAO Yun-cai, LI Zi-li, ZHOU Zu-tao   

  1. College of Veterinary Medicine,Huazhong Agricultural University/Hubei Key Laboratory of Preventive Veterinary Medicine/Hubei Engineering Research Center of Biofermentation Feed,Wuhan 430070,China
  • Received:2021-08-19 Online:2021-12-25 Published:2022-01-04

摘要: 选取1日龄AA肉鸡288只,随机分为对照组(基础日粮)、抗生素组(基础日粮中+50 g/t金霉素)和发酵中药制剂组(基础日粮+3 kg/t发酵中药制剂),试验周期为42 d,研究发酵中药制剂对肉鸡生产性能、血清抗氧化指标、免疫功能、肠道形态和盲肠菌群的影响。结果表明,发酵中药制剂组出栏均重高于对照组和试验组,平均日增重比对照组和抗生素组分别提高8.19%(P<0.05)和4.61%(P<0.05),料肉比与对照组显著降低,比抗生素组降低0.02(P>0.05);发酵中药制剂改善了血清抗氧化指标;与抗生素组相比,发酵中药制剂组胸腺指数增加了61.96%(P<0.05),血清IL-1β、内毒素的含量分别降低28.73% (P<0.05)、23.36%(P<0.05),IL-6、IL-10含量分别提高117.63%(P<0.05)、36.85%(P>0.05)。发酵中药制剂组回肠、盲肠黏膜sIgA含量较对照组分别增加44.2%(P<0.05)和66.9%(P<0.05),较抗生素组分增加43.4%(P<0.05)和65.5%(P<0.05)。相比对照组和抗生素组,发酵中药制剂组回肠、盲肠VH/VD值显著提高。发酵中药制剂组乳酸杆菌含量最高,比对照组和抗生素组提高40.66%、24.27%(P<0.05),普氏粪杆菌的数量提高了12.44%和3.42%(P<0.05),沙门氏菌含量比对照组和抗生素组降低了17.76%、20.96%(P<0.05)。发酵中药制剂具有良好的益生功能,可以提高机体的抗病力,调节肠道形态结构及有益菌群,促进生产性能。

关键词: 发酵中药制剂, 抗生素, 肉鸡, 生产性能, 免疫功能, 菌群

Abstract: The purpose of this study is to evaluate the effects of fermented Chinese medicine (FCM) on broiler production performance, serum antioxidant index, immune function, intestinal morphology and caecum flora, and provide technical support for the application of FCM preparation in broiler production. A total of 288 1-day-old AA broilers were randomly divided into 3 groups, the control group was fed with basal diet, the antibiotic group was fed with basal diet containing 50 g/t chlortetracycline, and the FCM preparation group was fed with basal diet supplemented with 3 kg/t probiotic FCM preparation. The experimental period was 42 days. The results showed that the output weight of FCM preparation group was higher than that of control group and test group. Compared with the control group and the experimental group, the average daily gain of FCM group was increased by 8.19% (P<0.05) and 4.61% (P<0.05), respectively. The feed to meat ratio was significantly decreased by 0.02 (P>0.05) compared with the antibiotic group. The serum antioxidant index was improved by FCM preparation. Compared with the antibiotic group, the thymus index of the FCM group increased by 61.96% (P<0.05), and serum IL-1β, the content of endotoxin decreased by 28.73% (P<0.05) and 23.36% (P<0.05), and the content of IL-6 and IL-10 increased by 117.63% P<0.05) and 36.85% (P>0.05), respectively. Compared with the control group and antibiotic group, the sIgA content of ileum and cecum in the FCM group increased by 44.2% (P<0.05) and 66.9% (P<0.05) respectively, and 43.4% (P<0.05) and 65.5% (P<0.05) respectively. Compared with the control group and antibiotic group, the VH/VD values of ileum and cecum in the FCM preparation group were significantly increased. Compared with the control group and antibiotic group, the content of Lactobacillus in the FCM preparation group was the highest, increased by 40.66% and 24.27% (P<0.05), the number of Faecalis prussii increased by 12.44% and 3.42% (P<0.05), and the content of Salmonella decreased by 17.76% and 20.96% (P<0.05). The FCM preparation had good probiotic function, which could improve the disease resistance, regulate the intestinal morphology and beneficial flora, and promote the production performance.

Key words: fermented Chinese medicine preparation, antibiotics, broilers, production performance, immunity, flora

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