关键词: 大黄(Rheum officinale Baill.), 大承气汤, 内毒素, 一氧化氮, 肿瘤坏死因子(TNF-α);

Abstract: Aiming to study the effect of Dachengqi decoction of raw rhubarb and steamed rhubarb on serum endotoxin,NO and TNF-α levels,105 experimental animals were randomly divided into Dachengqi decoction group,positive control group,blank control group and model group with raw rhubarb and steamed rhubarb.After 20 mL/kg dose administration,the contents of serum endotoxin,nitric oxide and tumor necrosis factor were measured,and the effects of Dachengqi decoction of raw rhubarb and steamed rhubarb on serum endotoxin,nitric oxide and tumor necrosis factor in mice were compared.Result showed that,Dachengqi decoction group of raw rhubarb and steamed rhubarb can increase the serum NO content of ABP mice.The Dachengqi decoction group of raw rhubarb and steamed rhubarb can reduce the serum endotoxin and TNF-ɑcontent of ABP mice.Dachengqi decoction with raw rhubarb and steamed rhubarb has different effects on the content of endotoxin,NO and TNF-α.These changes correspond to the effect of Dachengqi decoction of raw rhubarb and steamed rhubarb,and the he change of the content of the ingredients has a certain influence and commonality on the efficacy of Dachengqi decoction to a certain extent.

Key words: rhubarb(Rheum officinale Baill.), Dachengqi decoction, endotoxin, NO, TNF-α