组蛋白去乙酰化酶抑制剂对核移植胚胎体外发育效果影响的研究进展

doi:10.14088/j.cnki.issn0439-8114.2020.18.001

湖北农业科学 ›› 2020, Vol. 59 ›› Issue (18): 5-8.doi: 10.14088/j.cnki.issn0439-8114.2020.18.001

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组蛋白去乙酰化酶抑制剂对核移植胚胎体外发育效果影响的研究进展

吕玲燕¹, 吴永绍¹, 张家庆², 孙如玉¹, 汪燕玲¹, 潘天彪¹, 陈宝剑¹, 谢炳坤¹

1.广西壮族自治区畜牧研究所/广西家畜遗传改良重点实验室,南宁 530001;
2.河南省农业科学院畜牧兽医研究所,郑州 450002

收稿日期:2020-03-20 发布日期:2020-11-05
通讯作者: 陈宝剑,助理研究员,主要从事动物育种及种质资源保护工作,（电子信箱）hubao_117@163.com;
作者简介:吕玲燕（1985-）,女,广西桂林人,硕士,主要从事动物胚胎工程和分子遗传育种研究,（电话）13481192047（电子信箱）llyan159@163.com;谢炳坤,副研究员,主要从事分子遗传育种研究,（电子信箱）bkxie@163.com。
基金资助:
广西青年科学基金项目（2018GXNSFBA281105）; 广西水产畜牧科技推广应用项目（桂渔牧科201633011）; 广西水产畜牧科技推广应用项目（桂渔牧科201452007）

Research progress on the effects of histone deacetylase inhibitors on in vitro developmental competence of nuclear transfer embryos

LYU Ling-yan¹, WU Yong-shao¹, ZHANG Jia-qing², SUN Ru-yu¹, WANG Yan-ling¹, PAN Tian-biao¹, CHEN Bao-jian¹, XIE Bing-kun¹

1. Guangxi Key Laboratory of Livestock Genetic Improvement/Guangxi Institute of Animal Sciences, Nanning 530001, China;
2. Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China

Received:2020-03-20 Published:2020-11-05

摘要/Abstract

摘要： 组蛋白去乙酰化酶抑制剂（HDACi）是一类化合物,通过干扰组蛋白去乙酰化酶来控制DNA缠绕于组蛋白的松紧程度从而发挥作用,它可以通过增加细胞内组蛋白的乙酰化程度提高乙酰化相关基因的表达水平。近年来,关于HDACi促进供体细胞及核移植重构胚的表观遗传重编程以及调控高等动物机体基因的表达等相关研究备受关注。主要阐述了HDACi对核移植胚胎体外发育效果的影响,旨在为提高克隆胚胎的生产效率提供参考依据。

关键词: 组蛋白去乙酰化酶抑制剂, 核移植, 胚胎, 发育效果

Abstract: Histone deacetylase inhibitor （HDACi） is a class of compounds that can interfere with histone deacetylase to control the tightness of DNA binding to histones and play a role, which can increase the degree of histones acetylation in cells and improve the expression level of acetylated genes. In recent years, the researches on HDACi promoting epigenetic reprogramming of donor cells and nucleartransfer embryos and regulating the genes expression in higher animals have attracted much attention. The effects of HDACi on the in vitro developmental competence of nuclear transfer embryos are mainly described, in order to provide reference for improving the production efficiency of cloned embryos.

Key words: histone deacetylase inhibitors, nuclear transfer, embryos, developmental competence

中图分类号:

Q132.4

吕玲燕, 吴永绍, 张家庆, 孙如玉, 汪燕玲, 潘天彪, 陈宝剑, 谢炳坤. 组蛋白去乙酰化酶抑制剂对核移植胚胎体外发育效果影响的研究进展[J]. 湖北农业科学, 2020, 59(18): 5-8.

LYU Ling-yan, WU Yong-shao, ZHANG Jia-qing, SUN Ru-yu, WANG Yan-ling, PAN Tian-biao, CHEN Bao-jian, XIE Bing-kun. Research progress on the effects of histone deacetylase inhibitors on in vitro developmental competence of nuclear transfer embryos[J]. HUBEI AGRICULTURAL SCIENCES, 2020, 59(18): 5-8.

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组蛋白去乙酰化酶抑制剂对核移植胚胎体外发育效果影响的研究进展

Research progress on the effects of histone deacetylase inhibitors on in vitro developmental competence of nuclear transfer embryos

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