气相色谱-质谱法/MRM测定生活饮用水中N-二甲基亚硝胺（NDMA）的方法研究

doi:10.14088/j.cnki.issn0439-8114.2018.07.025

湖北农业科学 ›› 2018, Vol. 57 ›› Issue (7): 108-110.doi: 10.14088/j.cnki.issn0439-8114.2018.07.025

气相色谱-质谱法/MRM测定生活饮用水中N-二甲基亚硝胺（NDMA）的方法研究

赵丽, 师真, 洪雪花, 李文廷, 张瑞雨

昆明市疾病预防控制中心,昆明 650228

收稿日期:2017-11-14 发布日期:2020-01-14
通讯作者: 张瑞雨（1984-）,男,云南昆明人,初级理化检验师,主要从事理化检验工作,（电子信箱）417640514@qq.com。
作者简介:赵丽（1984-）,女,云南昆明人,中级理化检验师,硕士,主要从事理化检验工作,（电话）13629687652（电子信箱）zhaoli880@126.com;
基金资助:
昆明市卫生科技项目[s（后备）-69]

GC-MS/MRM determination of N-Nitrosodimethylamine（NDMA） in Drinking water

ZHAO Li, SHI Zhen, HONG Xue-hua,LI Wen-ting, ZHANG Rui-yu

Kunming City Center for Disease Control and Prevention,Kunming 650228,China

Received:2017-11-14 Published:2020-01-14

摘要/Abstract

摘要： 建立了一种适合于测定生活饮用水中的N-二甲基亚硝胺（NDMA）含量的气相色谱-质谱法（GC-MS）/MRM方法。通过对色谱柱、扫描方式、萃取溶剂、pH和浓缩方式的优化,建立了液液萃取气相色谱-质谱/MRM方法测定生活饮用水中的NDMA。NDMA在0.05~1.00 mg/L线性良好,检出限为0.01 μg/L（S/N=3）。对实际水样进行低、中、高3个不同浓度的加标回收率为66.93%~85.32%,相对标准偏差（RSD）为2.93%~4.19%。该方法灵敏度高、线性范围广、优化了生活饮用水中NDMA的检测条件,适用于生活饮用水中NDMA的检测。

关键词: 生活饮用水, N-二甲基亚硝胺（NDMA）, 气相色谱-质谱/MRM（GC-MS/MRM）

Abstract: A analytical method was developed for determination on N-nitrosodimethylamine by GC-MS/MRM. The determination of NDMA in drinking water by gas chromatography-mass spectrometry/MRM method was established by the optimization of chromatographic column,scanning mode,extraction solvent,pH and concentration method. Linear relationship between the peak area and concentration of NDMA was obtained in the range of 0.05~1.0 mg/L. The detection limit was 0.01 μg/L（S/N=3）.Tests for recovery and precision of this method were 66.93%~85.32% and the relative standard deviation（RSD） was 2.93%~4.19% by adding 2 different concentrations. The method has high sensitivity,wide linear range and optimized the detection conditions of NDMA in drinking water,and it is suitable for the detection of NDMA in drinking water.

Key words: drinking water, N-nitro sodimethylamine（NDMA）, GC-MS/MRM

中图分类号:

O657

赵丽, 师真, 洪雪花, 李文廷, 张瑞雨. 气相色谱-质谱法/MRM测定生活饮用水中N-二甲基亚硝胺（NDMA）的方法研究[J]. 湖北农业科学, 2018, 57(7): 108-110.

ZHAO Li, SHI Zhen, HONG Xue-hua, LI Wen-ting, ZHANG Rui-yu. GC-MS/MRM determination of N-Nitrosodimethylamine（NDMA） in Drinking water[J]. HUBEI AGRICULTURAL SCIENCES, 2018, 57(7): 108-110.

参考文献

[1] CHOI J,VALENTINE R L.Formation of N-nitrosodimethylamine(NDMA)from reaction ofmonochloramine:A new disinfection by-product[J].Water Res,2002,36(4):817-824.
[2] FIDDLER W,PENSABENE J W,DOERR R,et al.Formation of N-nitrosodimethylamine from natrurally occurring quatomary commonium compounds and tertiary amines[J].Nature,1972,236:309.
[3] 梁闯,徐冰,夏圣骥,等.饮用水中痕量二甲基亚硝胺(NDMA)的SPE-LC-MS-MS检测方法建立[A].中国土木工程学会水工业分会全国给水深度处理研究会年会[C].北京:中国土木工程学会水工业分会,2010.
[4] SUN Z,LIU Y,ZHONG R.Theoretealinvesligation of N-nitrosodimethylamine formation from nitrnsation of trimethylamine[J].J Phys Chem A,2010,114(1):455-465.
[5] SEHREIHER I,MITCH W.Influence of the order of reagent addition on NDMA formation during chloramination[J].Environ Sci Technol,2005,39(10):3811-3818.
[6] 徐冰冰,陈忠林,齐飞,等.紫外光降解水中衡量NDMA的效能研究[J].环境科学,2008,29(7):1908-1913.
[7] AGENCY E P.Test methods for ebaluating solid wastes physical/chemical methods[M].Washington D C:United States Environmental Protection Agency(EPA),2000.
[8] RAKSIT A,JOHRI S.Determination of N-nitrosodimethylamine in environmental aqueous samples by isotope-dilution GC-MS/SIM[J].Journal of AOAC International,2001,84(5):1413-1419.
[9] PEREZ D M,ALATORRE G G,ALVAREZ E B,et al.Solid-phase microextraction of N-nitrosodimethylamine in beer[J].Food Chemistry,2008,107(3):1348-1352.
[10] LEE C,LEE Y,SCHMIDT C,et al.Oxidation of suspected N-nitrosodimethylamine(NDMA)precursor by ferrate(Ⅵ):Kineties and effect on the NDMA formation potential of natural waters[J].Water Research,2008,42(1-2):433-441.
[11] 陈忠林,徐冰冰,齐虹,等.高效液相色谱测定水中痕量亚硝基二甲胺[J].中国给水排水,2007,23(8):84-87.
[12] PEREZ R T,MARTINEZ-LOZANO C,TOMAS V,et al.Automated solid-phase extraction and high-performance liquid chromatographic determination of nitresamines using postceolumn photolysis and tris(2,2,4-bipyridyl)ruthenium(Ⅲ)chemiluminescence[J].A Journal A,2005,1077(1):49-56.
[13] CHEN Z,VALENTINE L.Formation of N-nitrosodimethylamine(NDMA)from humic substances in natural water[J].Environment Science and Technology,2007,41(17):6059-6065.
[14] 张光学,彭清涛,徐文国,等.气相色谱-质谱法测定含偏二甲肼污水中N-亚甲基二甲胺[J].理化检验(化学分册),2008,44(1):12-14.
[15] 刘清明,张雪晨,周全,等.一种基于气相色谱-质谱检测水质N-亚甲基二甲胺(NDMA)的固相萃取方法[J].环境化学,2011, 3(7):1327-1331.

气相色谱-质谱法/MRM测定生活饮用水中N-二甲基亚硝胺（NDMA）的方法研究

GC-MS/MRM determination of N-Nitrosodimethylamine（NDMA） in Drinking water

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价