湖北农业科学 ›› 2018, Vol. 57 ›› Issue (21): 93-96.doi: 10.14088/j.cnki.issn0439-8114.2018.21.023

• 贮藏·加工 • 上一篇    下一篇

萱花草总皂苷的微波提取及其抗肿瘤活性研究

刘立新a, 张雪松b, 张羽男a, 叶之慧c, 孙晶b, 于海涛b, 李晶d, 王晶b, 罗文泽d, 张强e   

  1. 佳木斯大学,a.药学院;
    b.附属第一医院;
    c.附属口腔医院;
    d.基础医学院;
    e.公共卫生学院,黑龙江 佳木斯 154007
  • 收稿日期:2018-04-27 出版日期:2018-11-10 发布日期:2020-01-13
  • 作者简介:刘立新(1978-),女,黑龙江佳木斯人,讲师,博士,主要从事天然药物药效学与毒理学研究工作,(电话)15765305395(电子信箱)liulixin5395@163.com
  • 基金资助:
    黑龙江省卫生计生委科研课题(2016-297; 2018-492); 国家自然科学基金项目(81641120)

Study on Microwave Extracting and Antitumor Activity of Total Saponins from H.emerocallisfulva

LIU Li-xina, ZHANG Xue-songb, ZHANG Yu-nana, YE Zhi-huic, SUN Jingb, YU Hai-taob, LI Jingd, WANG Jingb, LUO Wen-zed, ZHANG Qiange   

  1. a.School of Pharmacological Sciences;
    b.First Affiliated Hospital;
    c.Department of Stomatology,First Affiliated Hospital;
    d.School of Basic Medical Sciences;
    e.School of Public Health,Jiamusi University,Jiamusi 154007,Heilongjiang,China
  • Received:2018-04-27 Online:2018-11-10 Published:2020-01-13

摘要: 以微波功率、提取时间和原料固液比为主要因素,采用L9(33)正交试验进行微波辅助提取萱花草(H.emerocallisfulva)总皂苷工艺条件的优化,所得最佳提取工艺条件为微波功率420 W、提取时间45 s、原料固液比1∶50(g∶mL)。采用SRB法研究萱花草总皂苷对人肝癌HepG2细胞的体外抗肿瘤活性,试验结果表明萱花草总皂苷对人肝癌HepG2细胞株有良好的抗肿瘤活性,且优于人参皂苷Rb1的阳性对照组。

关键词: 萱花草(H.emerocallisfulva), 总皂苷, 微波辅助提取, 抗肿瘤活性

Abstract: Using microwave power, extracted time and solid-liquid ratio as main factors, the L9(33) orthogonal design was used for optimizing the extraction conditions of total saponins from H.emerocallisfulva. The optimum conditions were as:microwave power at 420 W,45 s of extracted time and solid-liquid ratio at 1∶50(g∶mL). Antitumor activity of total saponins from H.emerocallisfulva was studied by the SRB assay,the result shows that total saponins from H.emerocallisfulva demonstrated good antitumor activity on human hepatoma HepG2 cells,and better than the ginsenosides Rb1.

Key words: H.emerocallisfulva, total saponins, microwave extraction, antitumor activity

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