三种抗菌药物对羊源大肠杆菌抗菌活性的研究

doi:10.14088/j.cnki.issn0439-8114.2018.01.022

湖北农业科学 ›› 2018, Vol. 57 ›› Issue (1): 86-88.doi: 10.14088/j.cnki.issn0439-8114.2018.01.022

三种抗菌药物对羊源大肠杆菌抗菌活性的研究

邵莉萍, 李宏胜, 妥鑫, 张继瑜

中国农业科学院兰州畜牧与兽药研究所/农业部兽药创制重点实验室,兰州 730050

收稿日期:2017-09-29 出版日期:2018-01-10 发布日期:2020-01-02
通讯作者: 张继瑜（1967-）,男,甘肃庆阳人,研究员,博士研究生导师,主要从事兽医药理学与毒理学研究,（电话）0931-2115278（电子信箱）infzjy@sina.com。
作者简介:邵莉萍（1991-）,女,甘肃张掖人,硕士,主要从事兽医药理学与毒理学研究,（电话）17139310173（电子信箱）shaolp1992@163.com
基金资助:
“十二五”国家科技支撑计划项目（2015BAD1101）; 国家现代农业产业技术体系专项（CAR-38）

Research on Antibacterial Activity of the Clinical Commonly Used Drugs Against E.coil

SHAO Li-ping, LI Hong-sheng, TUO Xin, ZHANG Ji-yu

Lanzhou Institute of Husbandry and Pharmaceutical Science,Chinese Academy of Agricultural Sciences/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture,Lanzhou 730050,China

Received:2017-09-29 Online:2018-01-10 Published:2020-01-02

摘要/Abstract

摘要： 采用微量肉汤稀释法测定最小抑菌浓度（MIC）,研究抗菌药物恩诺沙星、环丙沙星、加替沙星对21株羊源大肠杆菌临床分离株的体外抗菌活性,从而观察大肠杆菌对几类抗菌药物的敏感性。结果表明,大肠杆菌对恩诺沙星、环丙沙星、加替沙星的敏感率分别为0.00、66.7%、61.9%,耐药率分别为47.6%、14.3%、33.3%。恩诺沙星、环丙沙星、加替沙星均对大肠杆菌产生不同程度的耐药性,其中恩诺沙星耐药性最强,而环丙沙星耐药性最弱。

关键词: 恩诺沙星, 加替沙星, 环丙沙星, 大肠杆菌, 耐药性：敏感性

Abstract: The broth microdilution method is used to determine MIC,which aims to evaluate the activity of the Enrofloxacin,Ciprofloxacin and Gatifloxacin against the clinical Escherichia coli from sheeps（21 isolates）,and the susceptible and resistance of the enrofloxacin,gatifloxacin and ciprofloxacin against E.coli was estimated. Result showed that,drugs susceptiblerates to Enrofloxacin,Ciprofloxacin and Gatifloxacin in E.coli are 0.00,66.7%,61.9%, and the drugs resistance rates to Enrofloxacin,Ciprofloxacin and Gatifloxacin in E.coli are 47.6%,14.3%,33.3%. Enrofloxacin,Ciprofloxacin,Gatifloxacin emerge the different resistantance to E.coil. The E.coil strains showed high drug resistance to Enrofloxacin,and showed low drug resistance to Ciprofloxacin.

Key words: Enrofloxacin, Gatifloxacin, Ciprofloxacin, Escherichia coli, drug resistance, sensibility

中图分类号:

S859.79⁺6

邵莉萍, 李宏胜, 妥鑫, 张继瑜. 三种抗菌药物对羊源大肠杆菌抗菌活性的研究[J]. 湖北农业科学, 2018, 57(1): 86-88.

SHAO Li-ping, LI Hong-sheng, TUO Xin, ZHANG Ji-yu. Research on Antibacterial Activity of the Clinical Commonly Used Drugs Against E.coil[J]. HUBEI AGRICULTURAL SCIENCES, 2018, 57(1): 86-88.

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三种抗菌药物对羊源大肠杆菌抗菌活性的研究

Research on Antibacterial Activity of the Clinical Commonly Used Drugs Against E.coil

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